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Ask Rolf Halden about antimicrobials during Aug. 29 Facebook Live chat.
FDA to ban harmful antimicrobials, thanks to ASU scientist's research.
August 25, 2017

Upcoming ban on personal-care products containing prominent antimicrobials a direct result of Rolf Halden's research

Arizona State University scientist Rolf Halden jokes that his real job is to scare the public, but in the course of his work he has made the public healthier.

Starting at the beginning of September, the Food and Drug Administration will prohibit the sale of personal-care products containing prominent antimicrobials, including triclosan and triclocarban — prized for their antimicrobial properties. The ban is a direct result of Halden’s research, which started in 2002.

“I want to rattle people’s cages to make them aware of what’s happening in our world,” said Halden, director of ASU’s Biodesign Center for Environmental Health Engineering and the lead author of the Florence Statement, a declaration signed by more than 200 scientists and medical professionals that laid out a convincing case against why these two antimicrobials are harmful.

“Oftentimes science is so detailed that the message can easily be lost, so I try to communicate what these things are about and why they’re important. They should be things we care about; otherwise, we shouldn’t be spending tax dollars on them.”

HaldenHalden is also a professor in the School of Sustainable Engineering and the Built Environment, part of the Ira A. Fulton Schools of Engineering, and a senior sustainability scientist in the Global Institute of Sustainability. has long contended triclosan and triclocarban are often ineffective in safeguarding the public from harmful microbes and, further, pose significant risks to human health and the environment by contaminating air, soil and water.

The FDA’s ruling only applies to consumer hand washes and soaps. The restriction does not extend to building and household products that are outside the purview of the FDA but still contain hazardous and ineffective antimicrobials sold throughout the U.S. and worldwide. Still, the FDA’s ruling is a major victory for consumers.

ASU Now caught up with Halden before his Aug. 29 Q&A, which will be livestreamed on ASU’s Facebook page starting at 11 a.m. Hosted by Knowledge Enterprise Development, the half-hour session will feature Halden discussing his work and answering audience questions. 

Question: You’ve often said it’s your job to scare people. What do you mean by that?

Answer: I want to rattle people’s cages to make them aware of what’s happening in our world. Everything that people encounter on the shelves at the store they believe is safe to use. But if you look at the underpinnings of what products and materials get manufactured into commerce, there are very few safeguards. The thing to remember is that we should never turn off our common sense and we should always ask questions.

For example, if you have ants or pests in your house and you go to the store to buy pesticides to kill them — if you decide to use these chemicals, beware that they could possibly do harm to you as well. When things are very powerful, they can work both ways — for the good and for the bad. So it’s my job is to make people think just a little bit more about their health and safety.

Q: There is an assumption that the FDA will safeguard us from all things that are unsafe. Is that expectation too lofty or naïve?

A: I think overall the FDA is doing a pretty good job. There are also mechanisms that tend to push products and chemicals which are not necessary and which pose risks in certain environments. There are marketing mechanisms that tend to increase the desire to have certain chemicals or products, resulting in mass production. The more you make of a problematic chemical, the bigger the risk that it harms you or that it gets around in your house, your country or around the globe.

We have many examples of chemicals that travel places and do any harm. Keeping an eye on production and making sure they aren’t running out of rudder with respect to volume is important. If something is declared safe but only was deemed to be used by a few, while all of a sudden the chemical is widely produced and used by everyone, it ramps up everything, including the risk. So ultimately it’s the responsibility of the consumer.

A lot of people say they hate chemistry, although chemistry is the science that makes up everything. Chemistry decides on the way you look and live, and is linked to emotions and behavior. It’s a very, very powerful and certainly underappreciated scientific discipline.

Q: How big of a victory is the FDA ruling?

A: Ultimately it’s rewarding for the science community — to see the results of their labor and work that translates into something tangible. This is an example where the work of many people has resulted in a conclusion that can help us protect people better if we can reduce these types of chemicals into our living environment. Ultimately it’s a very rewarding situation, and it doesn’t happen very often. It’s not common that chemicals get removed from products in the United States.

We must also understand these chemicals are not entirely disappearing. The FDA only regulates a certain amount of products under their purview. It’s in a lot of other products: carpets, socks, shoes, and other things that can be impregnated with triclosan and other antibacterials. There is still a need for vigilance on the side of the consumer to know that something can be harmful and avoided unless it’s really needed. It’s only being banned in soaps because it’s all the FDA. can do. There is still a need to translate this ban to other products as well.

Q: How often does the FDA listen to scientists, and how often does it change its mind when confronted with scientific evidence?

A: The FDA is always listening and absorbing science. There is an intrinsic problem with the fact that there’s always knowledge, and that knowledge gained is eventually added on. As a scientist, we tend to think that recent studies are always more thorough and better designed and therefore are more reliable. Industry, on the other hand, tends to go back to studies that are older and oftentimes did not report any adverse effects. It’s often the job of the FDA to weigh in on this and reach a fair judgment that keeps people safe.

For everything we study, there are always studies that show there are potential problems. It’s a delicate process to decide whether or not the integration of these types of chemicals ultimately serves public health or not. The FDA reached the right conclusion in removing these antimicrobial chemicals from the market.

Q: Let’s discuss triclosan and triclocarban and the impacts they have on people and the environment.

A: Triclosan and triclocarban are chemicals that resemble in many ways the chemicals that we mass-produced and then banned in the 1970s. Things like DDTDichloro-diphenyl-trichloroethane (DDT) were produced as the first of the modern synthetic insecticides in the 1940s. It was initially used to combat malaria, typhus and the other insect-borne human diseases among both military and civilian populations. It also was effective for insect control in crop and livestock production, institutions, homes and gardens. comes to mind, and it was assumed to be safe at the time. We now know that this chemical is persistent and bio-accumulative. Once it gets stored into our body it stays with us for a long time. These are chemicals you want to avoid.

But we’ve done the opposite. We’ve really ramped up production and gone through millions of pounds. So for us now it is difficult to provide even a control sample of these chemicals because they are everywhere. They are in paints, carpets, sofas, and also get into the lab environment as unwanted contaminants. Nintey-seven percent of women in American have triclosan in their breast milk. It’s a chemistry that didn’t serve us well in the past and it needs to go away. It needs to be replaced with better chemistry, sustainable or greener chemistry that’s more compatible with nature. We should mass-produce products that do not destroy our environment.

Q: The ban will go into effect in September. Does President Donald Trump or any other entity have the power reverse this decision?

A: It would be undesirable to do so. This decision also involves a lawsuit and consent decree. So for that reason, this just isn’t a political move and is difficult to reverse in the United States. What we hope is that through the coverage of this ban other countries and nations will take a closer look at them.

Ultimately, we all live in one big bubble, our planet's atmosphere. When we ban a chemical here in the U.S. and it’s mass-produced in other places around the world, it still comes to us. We banned DDT in the 1970s, and it’s still being produced in other parts of the world. It actually travels atmospherically and comes back to visit and is detectable in everyone.

Q: Going forward, what’s the next problem or challenge you plan on tackling in this domain?

A: Triclosan and triclocarban and other antimicrobials are symptomatic only; we need to leapfrog from an old type of chemistry that has provided services but has come at great environmental cost. We need a new generation of chemicals.

It’s a difficult transition because we have built this pipeline that likes to take in fuel-based, non-recyclable resources. Ultimately, we have to make this transition because we are running out of the feedstocks we have used in the past. There are better alternatives. The challenge is to communicate the risk of existing chemicals and to build political momentum and the will to transition to safer and greener alternatives.

Q: What can consumers do on their end?

A: I would suggest they use common sense. Say if a chemical is advertised as killing a lot of things, it also probably poses risks to human health. If you decide to buy it, then it should probably be stored in a safe place. If you don’t need to have a product in your living space, or if you smell it all the time, it probably means you’re getting exposed.

For example, everybody loves new-car smell. Well, new-car smell is actually the plasticizers that come out of plastics and these chemicals are known to act as endocrine disruptors. So people need to change their mind-set about their sensory perception and what it means. If they can smell something that’s prominent, that should serve as a warning signal.

 

Top photo: ASU Professor Rolf Halden, director of the Center for Environmental Health Engineering at the Biodesign Institute, talks about his fight to get the FDA to ban two antimicrobial agents — triclosan and triclocarban — in one of the chemistry labs on the Tempe campus on Thursday. The ban takes effect in September for the chemicals' use in soaps. Photo by Charlie Leight/ASU Now

 
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AZLoop team places among top at hyperloop competition

August 27, 2017

Team made up of students from ASU, NAU and Embry-Riddle make it to top 8 at SpaceX

HAWTHORNE, California — AZLoop — a team made up of students from Arizona State University, Embry-Riddle Aeronautical University and Northern Arizona University — finished in the top eight out of 35 teams this weekend at the second hyperloopHyperloop is a new form of proposed mass transit that promises to hit speeds of up to 750 mph. competition sponsored by SpaceX.

The winner was the German WARR team, with a top speed of 201 miles per hour.

“Our team did extremely well while we were here,” AZLoop team co-lead Lynne Nethken said. “We succeeded with flying colors through all of the functional tests. ... The fact that we came in as a new team and we competed neck and neck and came out with the same amount of points as these teams who built last year is pretty incredible.”

The AZLoop team ended up with a total of 88 points, tying with the top teams running at the competition, all of whom had pods in competition last year.

With the knowledge their pod is able to compete at the highest levels, AZLoop is champing at the bit for the next competition

“Our pod is fully functional and ready to go in that tube,” team co-lead Josh Kosar said. “Everything we have to do is tweaking.”

Video by Ken Fagan/ASU Now

ASU designed a nozzle that turns a pressure vessel capable of producing 500 pounds of thrust into one that produces 5,000 pounds of thrust.

“It was actually kind of fun,” Kosar said. “We were aiming at 140 meters per second; this the max speed we can hit and still brake safely. Whereas a lot of the other teams around, the next highest speed we saw was aiming at 90 meters per second.”

Teams from 35 countries came to compete. The bar to bringing home a win was the fact that there was only one vacuum tube for competition, which took 30 to 45 minutes to depressurize and repressurize. Getting pods on and off the track was also time-consuming.

“At the end of the day, when it comes to getting into the hyperloop tube, there are only so many times they can do, especially in a vacuum environment, because it takes time to depressurize and repressurize the track,” Nethken explained.

Kyle Squires, dean of the Ira A. Fulton Schools of Engineering, praised the AZLoop's hard work.

“The team did an unbelievable job — going from essentially a standing start months ago to finishing near the top,” Squires said.

“What they created was indeed an engineering feat, and the passion, energy, drive and commitment put forth by everyone was amazing,” Squires said. “My hope is that this experience empowers and inspires these students and others to continue to push the limits on innovation.”

AZLoop is the only team with a test track and a vacuum chamber, giving them an edge in future. Their workspace and test track are at ASU’s Polytechnic campus.

“If they let us in there, we’d knock their socks off,” said Chris Kmetty, team adviser and an engineer with Markham Contracting, who built the test track. Kmetty is also an alumni, part of the Class of 1997.

“I didn’t see any sad faces,” said Quoc Lam, a ASU senior majoring in mechanical engineering, Barrett honors student and vice president of AZLoop.

“What I got out of it was a lot of experience and team building,” Lam said. “I’ve never worked at this level before.”

A self-described introvert, Lam said he shines in the lab with the team: “It’s the best experience in my life.”

Team members said they’re in excellent shape.

“We have the facilities, we have the pod, we have an amazing team, we have the support of the administration and of Arizona, so we’re really looking forward to being able to pick up again in September for competition 3 and doing this all over again and being one of the teams in the tube next year,” Nethken said.

Bugs were to be expected in testing and competing with a completely new form of technology, Nethken said.

“It’s the fifth mode of transportation, and it’s coming in the future,” she said. “That’s what we’re all doing here. We’re designing this new mode. Hopefully in 10 to 15 years we’ll see a full-scale existence of it, especially in Arizona. ... It’s pretty amazing. Not many students get to work on a new mode of transportation.”

Brendan Trang, an ASU senior in mechanical engineering, said he has never felt more inspired in his life. Being on the SpaceX campus, with rockets and pods on display and Teslas parked everywhere, planes roaring overhead out of the airport, was engineering heaven for Trang.

“I love it,” he said. “I’ve never been more excited about anything in my life. They say your happiest moment is when you get to college. This is it, right here. I’m sad we’re not able to run, but I’m excited to be here and be around these people. I’m excited to see Elon (Musk), if he ever comes out. That’s going to be the best day ever.”

Trang got his wish. Musk made a brief appearance late in the day. Trang had earned his day in the sun. He had stayed up for almost five days in a row, putting components on the chassis after it arrived.

“Honestly the toughest part was trying to stay awake just to get everything done,” he said. “When it finally got sent off, I was so relieved.”

The event was a cross between a street fair — with Ping-Pong and foosball tables, a disc jockey, food trucks and free Hawaiian ice — and an engineering convention, with booths, virtual reality and young engineers discussing actuators, magnets and propulsion.

“We’re going to build a better pod,” Trang said. “We’re going to build the one Elon picks, and we’re going to win next year.”

 

Top photo by Charlie Leight/ASU Now

Scott Seckel

Reporter , ASU Now

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