ASU-Pakistan partnership to help South Asian nation find sustainable energy


August 27, 2015

Arizona State University will help bring light to Pakistan via a partnership celebrated Thursday.

Officials gathered on the Tempe campus to mark the initiative, in which ASU is partnering with two top Pakistani universities for five years to hunt for energy solutions for the South Asian nation. Liz Schrayer, former U.S. Ambassador Kurt Volker and U.S. Sen. John McCain Sethuraman “Panch” Panchanathan, senior vice president for the Office of Knowledge Enterprise Development at ASU, speaks about the partnership Aug. 27. Download Full Image

More than 70 percent of the Pakistani population does not receive steady electricity. About 1,200 people died in Karachi this summer because of lack of power for air-conditioning and water pumps, according to a U.S. government official at the event.

The collaboration will focus on applied research relevant to Pakistan’s energy needs. Together academia, industry and the Pakistani government will work to formulate a sustainable energy policy.

The U.S. Agency for International Development (USAID) awarded the $18 million project to ASU to establish the Partnership Center for Advanced Studies in Energy (PCASE) in association with Pakistan’s National University of Science and Technology in Islamabad and the University of Engineering and Technology-Peshawar.

ASU has worked with USAID on more than $40 million in grant-awarded projects; currently more than 30 projects are active. The grant to establish the Pakistani partnership is the largest USAID grant received by ASU to date.

“There are parts of Islamabad today that are without energy most of the time,” U.S. Sen. John McCain (R-Ariz.) said at the Thursday event. “I believe that this development will have a direct impact on the people of Pakistan.”

Sethuraman “Panch” Panchanathan, senior vice president for the Office of Knowledge Enterprise Development at ASU, said McCain is a senator who thinks globally.

“We are so fortunate to have him here today,” Panchanathan said.

Lately the two Pakistani universities have initiated programs that the population needs, said Mohammad Shahid, the pro rector of the National University of Sciences and Technology in Islamabad.

“We want to fill in the gaps,” Shahid said. “There is a dire need.”   

It’s vital the project makes life better for the people of Pakistan, said Syed Imtiaz Hussain Gilani, vice chancellor with the University of Engineering and Technology in Peshawar.

“With things calming down in the political arena, I think this is the time for the private sector to come in and invest,” Gilani said. “It’s a country that needs everything, not just energy. … I hope the frontier spirit I feel on this campus drives some people to come forward and invest.”   

The creation of the two energy research centers – one at each Pakistani university – is expected to improve U.S.-Pakistani relations.

Both countries’ interest in renewable energy supersedes whatever may be happening in the diplomatic realm, said Larry Sampler, assistant to the administrator in the Office of Afghanistan and Pakistan Affairs, USAID.

“Truly we are part of a wonderful team effort that going forward is going to do wonderful things,” Sampler said.

Scott Seckel

Reporter, ASU Now

480-727-4502

Fetal cells influence mom's health during pregnancy — and long after


August 28, 2015

Editor's note: This story is being highlighted in ASU Now's year in review. To read more top stories from 2015, click here.

Parents go to great lengths to ensure the health and well-being of their developing offspring. The favor, however, may not always be returned. An illustration shows that fetal cells may have an influence on a mother's body Dramatic research has shown that during pregnancy, cells of the fetus often migrate through the placenta, taking up residence in many areas of the mother’s body, where their influence may benefit or undermine maternal health. Photo by: Jason Drees/Biodesign Institute Download Full Image

Dramatic research has shown that during pregnancy, cells of the fetus often migrate through the placenta, taking up residence in many areas of the mother’s body, where their influence may benefit or undermine maternal health.

The presence of fetal cells in maternal tissue is known as fetal microchimerism. The term alludes to the chimeras of ancient Greek myth — composite creatures built from different animal parts, like the goat-lion-serpent depicted in an Etruscan bronze sculpture.

According to Amy Boddy, a researcher at Arizona State University’s Department of Psychology and lead author of a new study, chimeras exist. Indeed, many humans bear chimerical traits in the form of foreign cells from parents, siblings or offspring, acquired during pregnancy.

“Fetal cells can act as stem cells and develop into epithelial cells, specialized heart cells, liver cells and so forth. This shows that they are very dynamic and play a huge role in the maternal body. They can even migrate to the brain and differentiate into neurons,” Boddy said. “We are all chimeras.”

Fellow ASU researchers Angelo Fortunato, Melissa Wilson Sayres and Athena Aktipis joined Boddy for the new study. Fortunato is with the Biodesign Institute’s Human and Comparative Genomics Lab. Wilson Sayres and Aktipis — both with Biodesign’s Center for Evolution and Medicine — are also researchers with ASU’s School of Life Sciences and Department of Psychology, respectively.

Mother’s little helpers?

Although fetal microchimerism is a common occurrence across placental mammals (including humans), the effects of such cells on maternal health remain a topic of fierce debate in the biological community.

In research appearing in the advanced online edition of the journal Bioessays, Boddy and her colleagues review the available literature on fetal microchimerism and human health, applying an evolutionary framework to predict when fetal cells are inclined to act cooperatively to enhance maternal health and when their behavior is likely to be competitive, occasionally leading to adverse effects on the mother.

Fetal cells may do more than simply migrate to maternal tissues. The authors suggest they can act as a sort of placenta outside the womb, redirecting essential assets from the maternal body to the developing fetus. Cells derived from the fetus — which can persist in maternal tissues for decades after a child is born — have been associated with both protection and increased susceptibility to a range of afflictions, including cancer and autoimmune diseases like rheumatoid arthritis.

But, as co-author Wilson Sayres, cautions, “it’s not only a tug of war between maternal and fetal interests. There is also a mutual desire for the maternal system to survive and provide nutrients and for the fetal system to survive and pass on DNA.” 

If some degree of fetal microchimerism exerts a beneficial effect on maternal and offspring survival, it will likely be selected by evolution as an adaptive strategy.

A review of existing data on fetal microchimerism and health suggests that fetal cells enter a cooperative relationship in some maternal tissues, compete for resources in other tissues and may exist as neutral entities — hitchhikers simply along for the ride. It is likely that fetal cells play each of these roles at various times.

For example, fetal cells may contribute to inflammatory responses and autoimmunity in the mother, when they are recognized as foreign entities by the maternal immune system. This may account in part for higher rates of autoimmunity in women. (Women have three times higher rates of rheumatoid arthritis, compared with men.)

Fetal cells can also provide benefits to mothers, migrating to damaged tissue and repairing it. Their presence in wounds — including cesarean incisions — points to their active participation in healing. In other cases, fetal cells from the placenta are swept through the bloodstream into areas including the lungs, where they may persist merely as bystanders.

 

Fetal Microchimerism & Maternal Health V6-HD from Biodesign Institute at ASU on Vimeo.

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Applying a cooperation and conflict approach, the authors make testable predictions about the circumstances favoring fetal cell cooperation or competition and attendant positive or negative effects on maternal health. 

“Cooperation theory and evolutionary analyses are powerful tools for helping us to unravel the complex effects of fetal cells on the maternal body. They can help us to predict when fetal cells are likely to contribute to maternal health and when they may be manipulating maternal tissues for the benefit of the offspring and potentially contributing to maternal disease in the process,” Aktipis said.

Evolutionary theory suggests that fetal cells will act cooperatively to enhance maternal health where the economic cost of doing so is low, for example, in tissue maintenance. Where the cost to fetal cells is high, including the division of limited resources between fetus and mother, competition is the more likely outcome, with escalating conflict leading to harmful effects for mother, developing fetus or both. 

Fetal cells appear to play a complex role in the female breast and have been detected in more than half of all women sampled. Given the co-evolution of maternal and fetal cells over the 160-million-year course of placental mammalian evolution, it appears likely that fetal cells are active participants in breast development and lactation. 

Milk production is a vital but energy-intensive activity for the mother, requiring subtle regulation. Poor lactation — a common affliction — may be linked with low fetal cell count in breast tissue. The hypothesis suggests that a simple, non-invasive test for fetal cell abundance in breast milk could provide the first conclusive evidence of fetal cell influence on maternal health.

With respect to breast cancer, existing data paints a complex picture. Fetal cells are generally found in lower abundance in women with breast cancer, compared with healthy women, suggesting they may play a protective role. On the other hand, some data indicates that fetal cells may be linked with a transient increase in the risk of breast cancer in the years immediately following pregnancy.

The thyroid gland performs a broad range of regulatory functions and, during pregnancy, is involved in the efficient transfer of heat from the mother to the offspring. Again, fetal cells found in the thyroid are implicated and may be manipulating thyroid activity to enhance heat transfer to the fetus, potentially at the energetic expense of the mother.

Fetal cells occur more frequently in both the blood and thyroid tissue of women with thyroid diseases including Hashimoto’s thyroiditis, Graves’ disease and thyroid cancer, compared with healthy women. (Intriguingly, cancer of the thyroid is the only non-sex-specific form of cancer found more frequently in women than men.) The authors suggest that the maternal system, in attempting to wrest control from fetal cell influence, may induce hazardous levels of autoimmunity and inflammation.

Fetal attraction

The current overview represents a tentative step toward untangling the myriad influences of fetal microchimerism on human health. One of the more tantalizing possibilities raised in the new study is that fetal cells may be commandeering neural pathways overseeing emotion and behavior. They may, for example, hijack mechanisms triggering the release of oxytocin, a hormone long associated with the emotional bonding of mother and infant.

Indeed, fetal cells could be suspects in a broad range of physical and emotional manifestations in the mother, including pregnancy-related afflictions like morning sickness or postpartum depression. Even early-onset menopause could be the result of fetal cell efforts to remove the mother from further child-bearing, in order to secure maximum resources for the fetus and, eventually, the growing child.  

Finally, the authors note, fetal microchimerism may be one piece of a subtle and dizzyingly complex puzzle. Cell traffic is actually bi-directional, with the fetus receiving cells from the mother. Fetal cells from maternal tissue may cross the placental barrier during subsequent pregnancies, potentially influencing the health of later offspring. To further complicate matters, cells from later fetuses can also cross the placenta to enter the microchimeric arena, perhaps introducing sibling rivalries for the mother’s limited resources.

Fetal cells may eventually provide a novel and powerful means of diagnosing existing conditions and predicting long-term maternal health. As the authors note, they could also be applied therapeutically in the future, potentially for the treatment of poor lactation, for wound healing, tumor reduction and perhaps even pregnancy-linked psychological disorders.

Identification of fetal cells in maternal gut, liver or brain tissues is only a first step. To tease out the true function of these cells, researchers need to examine their gene expression and interaction with maternal tissues. Inspection of maternal cells in surrounding tissue will help determine if they are immune cells targeting fetal cell interlopers or normal epithelial cells, existing in harmony.

“If future research bears out the predictions of this framework, it could transform the way we approach, treat and prevent a variety of diseases that affect women, especially new mothers,” Aktipis said.

Improved methods of screening will help scientists listen in on the intricate dialogue between fetal and maternal cells, deepening our understanding of maternal health and disease.

 

Media contact: Joe Caspermeyer, Biodesign Institute, Joseph.Caspermeyer@asu.edu, (480) 727-0369.

Richard Harth

Science writer, Biodesign Institute at ASU

480-727-0378