Two ASU geographers investigate COVID-19 challenges through a geospatial lens

Projects to investigate COVID-19 research credibility and food insecurities


October 12, 2020

COVID-19 caused a pandemic, but the challenges we face from it extend far beyond the virus. Two professors with Arizona State University's School of Geographical Sciences and Urban Planning have been selected for fellowships to further investigate these challenges.

The Geospatial Software Institute (GSI) Conceptualization Project, which is supported by the National Science Foundation, has selected 16 researchers from 13 institutions to tackle projects related to COVID-19 challenges using geospatial software and advanced capabilities in cyberinfrastructure and data science. A person wearing a mark reaches for grocery bags outside residence door The pandemic has required many people to replace in-store visits with online food shopping, an opportunity not afforded to those without internet access or a debit card. This disconnect has created food insecurities for many, a subject being researched by Daoqin Tong in the School of Geographical Sciences and Urban Planning. Photo courtesy of DepositPhotos.com.

Vetting research through replication and reproduction

Peter Kedron, assistant professor in the School of Geographical Sciences and Urban Planning and member of the school’s Spatial Analysis Research Center, will be using this fellowship to work with his colleague Joseph Holler, assistant professor at Middlebury College, to advance COVID-19 research through assessing credibility with reproductions and replications.

“To make the best possible decisions, we must know more than the results of recent COVID-19 research,” Kedron said. “We must also know how credible those results are because understanding the credibility of research allows us to appropriately weight findings when making decisions about pandemic response.”

To assess credibility, Kedron will incorporate students from ASU and Middlebury College into the research by working with them to see if the research can be reproduced and replicated.  

“Typically, we establish the credibility of research by conducting independent reproductions and replications,” Kedron explained. “However, the novelty and widespread impacts of COVID-19 have limited the opportunity to use reproductions and replications to assess what we think we know. This project will advance COVID-19 research by using reproductions to directly assess the reliability of the research projects of GSI fellows.”

The project will develop teaching modules, training materials, and a pedagogical model for teaching reproducible research practices, as well as the hands-on experience for students as they participate in a virtual workshop series on the tools and practices of reproducible research, support the development of pre-analysis plans, and attempt direct reproductions of COVID-19 research.

More people facing food insecurity during the pandemic

Even when not in the midst of a pandemic, many families and communities face food insecurity. When combined with the constraints of quarantine, including increasing unemployment rates, even more people are faced with this challenge.

“Adequate access to affordable healthy food has become a pressing societal issue due to the COVID-19 pandemic,” said Daoqin Tong, associate professor in the School of Geographical Sciences and Urban Planning and member of the school’s Spatial Analysis Research Center. “The number of families who are food insecure and in need of food assistance has increased substantially during COVID-19. Meanwhile, the social distancing requirement is changing the way that people access food with many people replacing in-store visits with online food shopping and pickup.”

To help understand this issue better, Tong’s project combines a large food access spatial dataset and relevant socioeconomic and demographic data to examine how economic stress and the new rules for obtaining food impact healthy food access during COVID-19. Her study will also produce a food access map to compare the patterns before and during COVID-19, examine the potential factors associated with the food access pattern change, and explore strategies that could be used to help improve healthy food access in disadvantaged neighborhoods.

“The project will be conducted in Maricopa County where healthy food access represents a critical challenge,” Tong said.

With a population of more than 4 million people, the region is among the fastest growing in the nation and one where food access and insecurity was a critical issue even prior to COVID-19.

“We plan to share the research findings through maps and summary statistics with food assistance programs, nonprofit organizations and government agencies in Maricopa County.”

ASU among esteemed group selected for GSI fellowship

The GSI Conceptualization Project is supported by the National Science Foundation, and carried out in partnership with the American Association of Geographers, Consortium of Universities for the Advancement of Hydrologic Science, Inc., the National Opinion Research Center at the University of Chicago, Open Geospatial Consortium, and University Consortium for Geographic Information Science. Technical and cyberinfrastructure support are provided by the CyberGIS Center for Advanced Digital and Spatial Studies at the University of Illinois at Urbana-Champaign. 

In total, 16 fellows from 13 institutions were selected to engage in projects of a wide range of subjects with roots in the COVID-19 crisis, including mobility patterns, access to health care and food systems, and racial and disability disparities during the pandemic.

“Geospatial data and tools have enormous potential for helping us address the challenges of COVID-19, and these 16 fellows have exactly the right qualifications and experience,” said Michael Goodchild, research professor in the School of Geographical Sciences and Urban Planning and chair of the NSF project advisory committee.

Manager, Marketing and Communication, School of Geographical Sciences and Urban Planning

480-965-1348

From a bundle of nerves to centered calm

A device developed by ASU research-based startup Hoolest Performance Technologies is relieving anxiety for Phoenix residents by using neuromodulation technology designed to enhance human performance


October 12, 2020

Preparing to give a big presentation. Starting on an important work project. Fighting through the distress of overcoming addiction. Living with the intrusive thoughts from a traumatic past. Facing the unknowns of a dangerous new virus and an uncertain future.

What do these circumstances have in common? They all induce anxiety. A graphic depicting a silhouette of a head with icons related to time, the brain, medication, meditation, performance and health. There are many approaches to treating stress and anxiety. Nick Hool, a biomedical engineering doctoral alumnus from the Ira A. Fulton Schools of Engineering at Arizona State University, is helping people in the Phoenix area with a drug-free, anxiety-relief investigational device developed by his startup, Hoolest Performance Technologies. Graphic by Rhonda Hitchcock-Mast/ASU Download Full Image

Anxiety comes from a range of stressors that vary from person to person and can affect your ability to get through the day.

Arizona State University alumnus Nick Hool wants to help — and so far has helped people in the Phoenix area using a drug-free, anxiety-relief investigational device developed by his neuroscience-research-based startup, Hoolest Performance Technologies.

Anxiety disorders affect nearly 1 in 5 people in the U.S. and are the most common mental illness. In 2020, the COVID-19 pandemic has people experiencing anxiety more than ever.

Prescription drugs like selective serotonin reuptake inhibitors, including Prozac, or benzodiazepines, such as Xanax, have been the most popular anxiety treatment for decades. While effective, medications come with a long list of negative side effects. Forms of psychotherapy like cognitive behavioral therapy have also become increasingly popular, but these methods can be expensive and sessions with a therapist are often not available on demand.

Mindfulness and meditation are also becoming more and more popular, and apps like Calm and Headspace have dominated the self-care mobile app space since 2019. These practices are also recommended by health care professionals at Mayo Clinic and the U.S. Department of Veterans Affairs.

These are helpful solutions for many, but the time and active focus required to experience their benefits can be difficult for some to master. So, Hool set out to create a different approach.

Developing a new tool for human performance and anxiety relief

As a competitive golfer in high school, Hool also experienced anxiety growing up. He was even prescribed medication for a time in high school, but experienced undesired side effects. This sparked his interest in exploring the physiological side of stress using biomedical engineering.

With the development of functional magnetic resonance imaging and other brain imaging technologies, scientists have been able to gain a better understanding of neurotransmitters (the brain’s chemical couriers) and chemicals like serotonin and dopamine that play a role in anxiety disorders. 

These technologies have also helped study the effects of activating major components of the autonomic nervous system, which unconsciously control and regulate various bodily functions. Promising results in treatment of anxiety and stress have been made by stimulating one nerve in particular: the vagus nerve.

Hool’s graduate research in the Ira A. Fulton Schools of Engineering at ASU focused on noninvasive vagus nerve stimulation and its role in quelling anxiety.

The vagus nerve controls the body’s natural relaxation mechanism, called the parasympathetic response. It triggers a feeling that’s the opposite of the tense, fight-or-flight reaction people often have in stressful situations. Instead, activating the vagus nerve naturally slows the heart rate, lowers blood pressure and helps relax muscle tension.

The vagus nerve can be stimulated noninvasively through electrode contact on the skin above the nerve as it runs up the neck, past the ear and into the brain.

It was this mechanism that became the focus when Hool started his company. He sought out neural engineering expert and Fulton Schools Associate Professor William “Jamie” Tyler to work in the Tyler Neurotechnology Lab and learn the neuromodulation ropes.

Tyler, co-founder of neuromodulation startup IST, ended up designing a unique doctoral program for Hool, whom he believed had the “qualities and characteristics to take an idea and turn it into something impactful.”

Using his experiences as a neurotechnology entrepreneur, Tyler coached Hool on a successful strategy for building a company. So in addition to conducting research and writing journal articles and a dissertation like a typical doctoral student, Hool also completed the steps for creating an entrepreneurial venture, filing patents and securing investors.

“Nick has done everything right,” Tyler said. “He listened, responded, adapted. What’s next for him is exciting.”

The result of Hool’s work was the development of a noninvasive vagal nerve stimulation, or nVNS, device that uses small electrical impulses to activate branches of the vagus nerve in and around the ear. The nVNS device can directly activate the body’s parasympathetic response and the regions of the brain associated with producing chemicals that affect anxiety and other mental conditions.

Hool teamed up with two other ASU engineering students at the time, John Patterson and Sami Mian, to found Hoolest in May 2017. They earned early success, winning the 2018 ASU Innovation Open and earning $100,000 in seed funding.

Since then, he and his small team have continued developing the technology. Hoolest became one of the first ventures invited to become part of the WearTech Applied Research Center, Phoenix’s wearable technology hub, for which Tyler was the founding director, as an impactful wearable medical technology startup.

“Hoolest is one of five companies currently redefining the experience of health and human performance at WearTech Applied Research Center, where our mission is to accelerate bringing breakthrough wearable solutions to market,” said Wes Gullett, operations director at WearTech.

“Nick and his team at Hoolest are building the first drug-free product poised to become FDA-cleared for immediate, acute anxiety relief. We are proud of Nick’s vision to create a product that can empower anyone to attain a drug-free solution, and the progress Hoolest has made since joining the WearTech Center.”

Now that Hool has graduated with his doctoral degree, entrepreneurial and technology development with Hoolest has been his main focus.

Hoolest’s nVNS device is not yet available to the public, but the company has been investigating the effects of the device in clinical studies over the past year. Several individuals have been able to take home prototypes to help Hool and his team actively investigate the effects of the device.

Finding clarity and new habits

Greg Sumner, a 46-year-old Phoenix resident and ASU alumnus, read about Hoolest and WearTech in ASU’s Thrive magazine. He lives less than a mile away from the WearTech Center in Central Phoenix and initially wanted to check out what sounded like an excellent tool for a close family member who is an Iraq War veteran who sometimes experiences debilitating PTSD. 

But Sumner, an airline captain as well as a sales management and strategic development professional, is no stranger to stress and anxiety himself. He soon realized he’d discovered a tool that could enhance his own life.

“Using the nVNS device has become a daily habit for me as a productivity-enhancing tool, and I seem to be sleeping better when using it at bedtime,” Sumner said. “I wake up ready to tackle the next day’s agenda.”

Cassandra Johnson, a 37-year-old Mesa mother of two, is also incorporating the nVNS device into her habits to overcome addiction, which can sometimes be accompanied by severe anxiety. She has struggled with a cycle of getting clean from her heroin addiction and relapsing.

Several months ago, Johnson heard about Hoolest through a family connection to Hool. In the time she’s used the nVNS device, it has become another tool to achieve her mind-body-spirit balance alongside practicing and teaching yoga.

“Anxiety is a physical thing, we carry stress physically in our necks. I put Hoolest’s device on the nerve and it shakes the tension loose and relaxes it. Or if I have racing thoughts and use it before bed it helps slow things down and clears them out,” Johnson said. “The device is a tool you can reach for that doesn’t have chemical consequences or ups and downs."

Read more about Sumner and Johnson’s experiences on Full Circle.

Applying engineering research for community impact

Entrepreneurship and tackling use-inspired research to serve the community are important tenets of the ASU and the Fulton Schools missions. Hool and his small startup team at Hoolest have excelled in these missions. 

In addition to Hool’s entrepreneurship-focused doctoral program with Tyler, being involved in a startup has helped another graduate student enhance his engineering education.

John Patterson, an ASU electrical engineering graduate student studying power systems engineering, has been developing prototypes for Hoolest since the earliest days of the startup, sketching ideas for the right combination of voltage, current and frequency to make an effective nVNS device. Patterson’s education in the Fulton Schools has equipped him with the skills to make a difference with technology innovation.

“ASU has provided a great deal of insight into how to create well-engineered systems, those that are controlled, safe, economical and environmentally sustainable,” Patterson said. “The design of the Hoolest nVNS devices has been consistently driven with these principles in mind.”

Patterson believes the combination of support from the ASU, the Fulton Schools and WearTech has been a crucial element to Hoolest’s success: a diverse network of innovators from whom they can draw knowledge and experience.

“The skilled entrepreneurs, engineers, makers and mentors we have met through WearTech and through startup competitions such as the ASU Innovation Open have been crucial in arming us with the business acumen and technical skills required to build up our medical device company,” Patterson said.

Learning the interdisciplinary skills needed to create a successful startup are the same that make applied research impactful for the community.

As Patterson learned about the range of applications the nVNS device could have — from treating acute anxiety to offsetting the need for aggressive drug-based therapies — he believed he was part of something that would serve a great mental health need in both the local and global communities.

“With every adjustment and design improvement I made to the devices, I felt that I was one step closer to helping real people ease their symptoms, and that was a phenomenal motivator for my work,” Patterson said. “To me, Hoolest has been a force multiplier: a way for my design effort as an individual to directly improve the lives of everyone in need of treatment.”

Hool says it’s hard to describe his feelings about the progress Hoolest has made so far.

“When I first started out, it was just a dream and an idea. In school, we are often taught to dream big and pursue ambitious ideas, but we are rarely taught about the work, dedication and endurance it takes to actually pursue a big idea and as a result I’ve never really seen any of my ideas come to life — until now,” Hool said. “Having a great team, a great mentor in Jamie and being part of Venture Devils helped me keep the momentum and after years of hard work, we actually had the device in our hand we had been dreaming of for years.” 

He remembers the first time a person suffering from anxiety used the nVNS device and reacted by saying it was unlike anything he had ever used and could change millions of people’s lives.

“I thought he was just saying that to make me feel good. It did make me feel good, but since then I really have seen the impact on real people in our local community,” Hool said. “I don’t think there is a better feeling than seeing your efforts actually make a difference in someone’s life, whether it is building a nerve stimulation device or even just sitting and talking with someone. It is all one long process, but it has been the most rewarding process I’ve ever been part of.”

Hoolest has continued to run clinical studies to gather data about the investigational device’s ability to improve human performance and alleviate severe anxiety. They’ve now started down the path toward Food and Drug Administration clearance for their nVNS device to relieve anxiety.

Since Hool and his team began the project, they wanted the device to be scientifically validated and based on clinical evidence.

“It takes a huge amount of time and resources to validate a medical device through clinical trials,” Hool said, “but we are making progress and expect to receive FDA clearance for our device soon.” 

He sees a bright future for both Hoolest and the range of solutions for people seeking mental health aids other than medications like Prozac and Xanax.

“There are so many new technologies being developed today that interface with the brain and modulate its activity, and the big pharmaceutical companies are taking notice,” he said. “As the drug-free trend continues, I believe Hoolest will play a significant role in shaping the future of mental health treatment.”

Hoolest is running a clinical study for people in the Phoenix metropolitan area who experience anxiety to try out Hoolest’s VNS device. If you are interested in participating, sign up on Hoolest’s website for more information.

Monique Clement

Communications specialist, Ira A. Fulton Schools of Engineering

480-727-1958