Table for 650, please: Second annual Herberger Institute Day is a creative smorgasbord


October 17, 2018

The energy at the second annual Herberger Institute Day was electric — so electric that after four solid hours of almost 100 creative workshops at Herberger Institute’s five schools and art museum, and after 650 faculty, students and staff from the institute joined each other for dinner and guided conversation on Forest Mall, a circle of people was still dancing.

And at the center of that circle, for one brief impromptu moment, was Herberger Institute Dean Steven J. Tepper, popping in his signature bow tie herberger day Ceramics Professor Susan Beiner demonstrates some cup-building techniques with a slab of clay, as part of the second annual Herberger Institute Day on Oct. 11. Download Full Image

The break-dancing dean was not the only difference at this year’s Herberger Institute Day: The number of people signed up for workshops almost doubled from 2017, with 2,333 registrations. And this year there were two film screenings after the communal dinner, including “The Shape of Water,” presented by ASU Film Spark at the Marston Exploration Theatre, which also featured a live talk-back with the movie’s "amphibian" star, Doug Jones.

“We are a creative city at the institute — 6,000 artists, designers, scholars — working, teaching and learning together,” Tepper said when the day was done. “You could feel the energy of that bustling city on Herberger Institute Day.”

Sofia Alvarez, a theatre design and production student who helped lead a life-casting workshop, appreciated the opportunity to experience other parts of the college.

“A lot of times people just stay in their buildings and people work within their little ecosystem that’s going on there,” she said. “It’s nice to get out of that bubble and collaborate and speak with others and kind of bridge that gap.”

Melita Belgrave, associate professor of music therapy, signed up for three workshops: Escape the Museum, Crafting Your Stress Away and SplashMob, a (movement-based) painting — using the artists' feet — outside Dixie Gammage.

“It was just a lot of fun,” Belgrave said. “Every activity that I did, I did not interact with anybody from the School of Music. So I was interacting with students and staff and faculty from all other units in Herberger Institute.”

Tepper, who sampled more than eight workshops, including ukulele, painting with sand and storytelling through film, noted that at each stop, “students around the table came from every single college. We are doing on Herberger Institute Day what we aspire to do on every day — provide opportunities and pathways for our students and faculty to move seamlessly across the institute — to access talent and ideas in every discipline, finding inspiration in creative adjacencies.”   

Reaston McManus, a photography undergraduate, found inspiration in a literal creative adjacency: “I’ve never been to Design North before, so I completely found a whole new building.”

McManus said his favorite part of the day was the dinner, dubbed #CreaTable, which he pronounced “delicious.” This year’s meal was the work of a group of undergraduate and graduate Herberger Institute students enrolled in an eight-week interdisciplinary class . Led by graduate student instructors Mallory Alekna and Young Nae Choi, with input from Institute Professors Liz Lerman and Michael Rohd and Herberger Institute Special Events Manager Nyomi Gruber, the students planned, organized and presented the food, activities and entertainment, which included a brass band, the Herberger String Quartet and a student DJ from the School of Music.

“The meal was incredible,” Tepper said. “Great music, great conversation. Six hundred and fifty of us, together. One student said to me, ‘If I were in another college, this wouldn’t be nearly as fun. But at Herberger Institute, every other creative discipline is fascinating to me, so I love this.’ I could not agree more. Herberger Institute Day is a beautiful and powerful expression of who we are.”  

Video by Herberger Institute for Design and the Arts

Deborah Sussman Susser

Communications and media specialist, Herberger Institute for Design and the Arts

480-965-0478

In the fight against Alzheimer’s, Down syndrome may hold vital clues


October 17, 2018

At first glance, Down syndrome and Alzheimer’s disease, two severe brain abnormalities, may seem to have little in common. Down syndrome is a hereditary disease, the source of which has long been recognized — a triplication of chromosome 21. By contrast, the overwhelming majority of Alzheimer’s cases (more than 95 percent) do not have a clear-cut genetic source. Instead, the disease, which usually becomes clinically apparent late in life, is caused by a perplexing constellation of factors. While these have been the focus of intense study for more than 100 years, few conclusive answers have come to light.

In new research, Antonella Caccamo and her colleagues explore a number of critical factors that appear to link the two illnesses. The current project will use Down syndrom (DS) as a window into the underlying mechanisms that may give rise to Alzheimer’s pathology. Using this complementary approach, her $3.1 million NIH grant will explore the effects of a critical protein complex known as mTOR. Antonella Caccamo's primary research interest is linked to dissecting the molecular mechanisms underlying the pathogenesis of Alzheimer’s disease (AD). Specifically, she uses complementary approaches to study the role of the mammalian target of rapamycin in AD, and to elucidate the link between Down syndrome and AD. Caccamo has 15 years of experience working on AD and a strong track record of productivity with more than 35 peer-reviewed publications. Download Full Image

In the healthy brain, mTOR is involved in a range of essential physiological processes. mTOR is a regulator of protein synthesis and degradation. It plays a critical role in cell growth, longevity and the formation of the cytoskeleton, which provides living cells with their shape and structure, and mTOR is vital to maintaining the proper energy balance in many tissues throughout the body. mTOR is also implicated in synaptic plasticity, neuronal recovery and the retention of memory.

Caccamo is a researcher in the ASU-Banner Neurodegenerative Disease Research Center. Much of her research focuses on investigating Down syndrome molecular alterations in the brain in order to shed new light on Alzheimer’s disease (AD).

“The ultimate goal of my research is to identify novel and clinically translatable targets, thus aiding in the development of new treatments for AD,” Caccamo said.

Learning from mTOR

Disruption of the mTOR pathway has been implicated in diseases including cancer, obesity and cardiovascular disease. Dysregulation of mTOR also plays an important role in diabetes and aging, two known risk factors for Alzheimer’s disease. Irregularities in mTOR functioning are linked to other neurodegenerative diseases and have been shown to give rise to two distinct neuropathologies: depositions in the brain of plaques composed of the protein amyloid beta (Aβ), and accumulations of another protein — known as tau — that aggregates within neuronal cell bodies, forming neurofibrillary tangles.

Plaques and tangles are the classic hallmarks of Alzheimer’s disease. Intriguingly, they also occur in the brains of virtually all patients with Down syndrome, some 60 percent of whom go on to develop Alzheimer’s disease by age 60. Interestingly, APP (amyloid precursor protein), a protein that when cleaved generates beta amyloid (Aβ), the toxic protein that accumulates in AD and DS brains, is located on chromosome 21, the same chromosome that is triplicated in Down syndrome.

Could disruption of the vital mTOR pathway offer clues to the development of plaques and tangles and the onset of dementia in both DS and AD patients? Is mTOR dysregulation also linked with a particular form of cell death known as necroptosis, likewise implicated in AD and DS pathology? Most importantly, can the investigation of the molecular drivers of AD pathology in DS patients provide a new window into the early mechanisms underlying the development of sporadic Alzheimer’s, the form of the disease that commonly strikes aging adults? These are some of the important questions Caccamo’s new study intends to address.

Relentless scourge

Alzheimer’s disease remains the only leading killer lacking any means of treatment, prevention or cure. The disease is pitiless in its systematic destruction of brain functioning, wiping memories clean and robbing the brain of its essential capacities, ultimately resulting in death — typically within eight to 10 years of clinical diagnosis, though in some cases, Alzheimer’s can drag on for as long as 20 years. The emotional toll on patients, caregivers and society is immense and rapidly mounting.

Additionally, the staggering economic burden currently figures in the hundreds of billions of dollars in the U.S. alone and is projected to top $1 trillion by 2050. The need for viable treatments and preventive strategies could not be more acute.

Today, researchers know that the onset of Alzheimer’s begins decades before its telltale signs become apparent. Some have gone so far as to say that while AD is usually thought of as a disease of old age, it may also be associated with adolescence when the early signposts of the disease are planted in the seemingly healthy brain. Many in the field believe that the best hope for arresting the ominous trajectory of the disease lies in identifying causal mechanisms at the earliest stage, and developing effective means of intervention before the brain is irreparably damaged.

Caccamo believes that mTOR dysregulation may be one such early mechanism, giving rise to AD pathology in aging adults as well as DS patients. Research has demonstrated that mTOR is hyperactive in specific brain regions in both AD and DS patients. mTOR hyperactivity is further associated with tau pathology as well as low levels of TSC2, a critical gene product that is believed to keep mTOR hyperactivity in check. Finally, preliminary data from Caccamo’s research indicates that cell loss in DS patients results in part from necroptosis, a unique form of cell suicide linked with dysregulation of mTOR. 

This combination of factors has led to the central hypothesis of the new study: Dysfunction of the TSC2 complex causes an increase in mTOR activity in DS, leading to AD-like neurodegeneration by inducing necroptosis.

Streams and tributaries of Alzheimer’s pathology

Caccamo’s new project, entitled "Identify common mechanisms of neurodegeneration between Alzheimer’s disease and Down syndrome," addresses these issues on several fronts. The first aim of the project is to identify the molecular mechanisms underlying mTOR hyperactivity in DS. Here, the association of dysfunctional TSC2 with mTOR hyperactivity is explored. What might be causing the downregulation of TSC2 leading to mTOR hyperactivity? Three possibilities are experimentally probed: the presence of epigenetic changes in TSC2 and mTOR, alteration of the turnover rate of the TSC2 protein and newly detected proteins that may likewise contribute to destabilizing the delicate TSC2/mTOR axis.

The second aim of the study is to determine the role of hyperactive mTOR in the development of AD-like phenomena in DS. Here, the hypothesis of hyperactive mTOR leading to AD pathologies, particularly Aβ plaques and neurofibrillary tangles, is explored using Ts65Dn mice, a genetic model of Down syndrome. Caccamo’s preliminary results show that mTOR hyperactivity precedes an increase in Aβ and tau levels and degeneration of cholinergic neurons in mice. By subtly increasing or decreasing mTOR signaling, the study will test the effects of reducing mTOR on Aβ and tau levels as well as degeneration of neurons in the mice. Further, increased mTOR levels will be examined to see if such changes increase AD-like pathology and cognitive deficits. Finally, the study will identify additional proteins falling under the regulation of hyperactive mTOR in DS.

Although the death of nerve cells in both Alzheimer’s and DS brains is a well-recognized occurrence associated with impaired cognitive ability, the mechanisms leading to cell death are still not well understood. The third aim of the new study will be to examine how mTOR hyperactivity contributes to neuronal loss. Earlier work by Caccamo and others suggests that a form of programmed cell death known as necroptosis contributes to the neurodegeneration typically observed in AD brains.

The third phase of the new study will investigate the hypothesis that hyperactive mTOR helps set this neurodegeneration process in motion by activating necroptosis pathways in the brain. Systematically modulating mTOR activity and necroptosis signaling in mouse neurons will be used to test this hypothesis. In addition to improving the understanding of the mechanisms leading to cell death in DS and AD, the research will help elucidate possible therapeutic targets for these two tragic afflictions.

Researchers have much to learn from in-depth studies like these, which delve into mTOR’s profound influence on the brain, in sickness and in health. In addition to its relevance in neurodegenerative disease, mTOR’s crucial role in the aging process may shed new light on other foundational issues in neuroscience.

Richard Harth

Science writer, Biodesign Institute at ASU

480-727-0378